Ultrafine pulverization technology of traditional Chinese medicine

With regard to the ultramicro pulverization of traditional Chinese medicine, researchers have given different names and concepts from different research angles, such as ultramicro granules of traditional Chinese medicine, ultramicro decoction pieces of single traditional Chinese medicine, ultramicro powder of traditional Chinese medicine, etc. Since the active ingredients of plant drugs and animal drugs are mainly distributed in cells and intercellular substance, and mainly in cells, some people call the pulverization of traditional Chinese medicine for the purpose of breaking the cells of traditional Chinese medicine "cell level micro pulverization", the traditional Chinese medicine micro powder obtained by cell level micro pulverization method is called "cell level traditional Chinese medicine micro powder", similarly, the traditional Chinese medicine prepared on the basis of cell level traditional Chinese medicine micro powder is called "cell level micro powder traditional Chinese medicine", It is called "micronized Chinese medicine" for short.

Someone put the particle size greater than 1 μ The powder of m is called "micro powder", and the particle size is less than 1 μ The fine powder of m is called "superfine powder". In fact, as far as the particle size of traditional Chinese medicine is concerned, micron and nanometer traditional Chinese medicine, which are still in the ascendant of research, also belong to traditional Chinese medicine superfine preparations. Lu Fuer et al. believed that "micronized traditional Chinese medicine preparation" belongs to cell level micro powder preparation, which is a new dosage form developed by using modern high-tech and traditional processing technology and preparation technology. It is generally believed that its particle size should be 1-75 μ m. The traditional Chinese medicine within the particle size range can maintain the inherent pharmacodynamic material basis of traditional Chinese medicine. "Micron traditional Chinese medicine" includes micron traditional Chinese medicine, micron extracts of traditional Chinese medicine, and micron traditional Chinese medicine preparations. It increases the rate of cell wall breaking of traditional Chinese medicine by more than 90%. The so-called "nano Chinese medicine" refers to the effective components, active parts, original drugs and compound preparations of Chinese medicine with particle size less than 100nm, which are made by applying nanotechnology. They are a kind of Chinese medicine powder after being nano sized. According to the above point of view, some researchers divide the ultrafine powder into micron (>1 μ m) , submicron (0.1-1 μ m) And nano scale (1-100nm), the ultra fine powder technology is divided into micro technology, sub micro technology and nano technology.

According to the current research progress, although there are many names of TCM ultrafine pulverizers, and the related concepts and connotations are different, most people believe that the ultrafine pulverization of TCM refers to the cell level micro pulverization of TCM, in which the heart size is 75 μ M below. With the continuous deepening of research work, the definition or concept of ultrafine pulverization of traditional Chinese medicine will be more scientific and accurate.

The cell wall breaking rate of TCM ultramicro pulverizer is high, which is conducive to drug release and absorption. The cell wall breaking rate of common crushed medicinal powder is low. When the medicine enters the body, the powder particles of the medicine powder will absorb water and expand, and the effective ingredients will be continuously released from the cell wall and cell membrane through diffusion. Diffusion requires a concentration difference between inside and outside the cell. When the concentration difference between inside and outside the cell is very small or balanced, the release rate of the effective ingredients will be very slow or even stop. The effective ingredients in the internal cells are sometimes expelled from the body before it is too late to release, so the effective therapeutic concentration is often not reached.

The traditional Chinese medicine after ultramicro pulverizer ultramicro pulverization has a high cell wall breaking rate. The effective components are exposed before they enter the body. After they enter the body, the soluble components are rapidly dissolved. Even the components with low solubility are tightly adhered to the mucosa of the gastrointestinal inner wall due to the strong adhesion of the ultramicro powder, so that the retention time in the gastrointestinal tract is prolonged, the absorption is more sufficient, and the absorption amount will also increase. Since most of the cell wall is destroyed during crushing, the effective ingredients do not need to be released through the cell wall and cell membrane. In this way, superfine powder crushing is far superior to ordinary crushing in terms of drug release speed and release amount. The mineral medicine can also reach microns after ultramicro pulverization, which is conducive to the absorption of medicine and the improvement of curative effect.